STUDY OF THE EFFECT OF PROPOFOL & ETOMIDATE AS AN INDUCTION AGENT ON HAEMODYNAMIC CHANGES DURING INDUCTION & ENDOTRACHEAL INTUBATION

Introduction: Laryngoscopy and subsequent tracheal intubation cause a fugitive tachycardia hypertension as result of sympathoadrenal stimulation. Careful selection anestheshetic is thus required, cardiovascular reserve decreased in certain patients, so to avoid undue depressions cardiac circulatory function Aims And Objectives: This randomized double blind prospective study had been designed for comparative evaluation inj propofol 2.5 mg/kg, Etomidate 0.3 mg/kg an induction agent on haemodynamic changes such HR, SBP, DBP, MAP oxygen saturation during also the adverse effects two drugs under Material Methods: After approval from medical ethics committee, Dr D Y Patil Medical College Hospital, Pune, was carried out sixty (60) patients undergoing elective surgeries standard general anesthesia. ? All were premedicated with Ondansetron 0.1mg/kg i.v., midazolam 0.02mg/kg fentanyl 2 mcg/kg i.v. pre-oxygenated 100% 3 min, all vital parameters recorded (T1) Group P received inj. group E 0.3mg/kg over 30 sec (T2) Inj succinylcholine muscle relaxant given after administering agent, laryngoscopy attempted appropriate sized endotracheal tube. laryngoscopy(T3), periodic monitoring at 1,2,3,5 10 minutes intervals post Further patient maintained O2 /N2O / Isoflurane Vecuronium top-ups when required At end surgery, reversed Glycopyrrolate 0.008mg/kg along Neostigmine 0.05mg/kg intravenously extubated gaining consciousness adequate power Patient shifted recovery room observed any side nausea, vomiting, Result: The demographic profile comparable. There no statistically considerable difference between groups respect baseline SpO2. decrease mean heart rate seen compared (T2), 1 2min, values significant value <0.05,.and DBP AND 1,2 3, 5 min p <0.05 Pain injection more 26 30(86.7%) than E, which Incidence myoclonus 23 30(76.7%) <0.05. In (6.7%) vomiting (10%) insignificant >0.05 Conclusion: A• Both, Propofol etomidate are safe agents maintains better stability propofol. However, Both associated effects/complication.